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Addiction Symptom Xanax... XanaxXanax addiction symptom xanax Measure... Xanax Addiction...
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xanax addiction
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Alprazolam (Xanax, Xanor) - Description
PHARMACOLOGICAL ACTION:
Alprazolam is an anxiolytic agent of the benzodiazepine
group. Benzodiazepines, including alprazolam, are
thought to bind to central nervous system benzodiazepine
receptors, thereby increasing the affinity of the
receptor for gamma-aminobutyric acid (GABA). GABA, an
inhibitory neurotransmitter, modulates the activity of
other neurotransmitter systems, including the
noradrenergic system
Pharmacokinetics:
The pharmacokinetics of alprazolam are linear over the
recommended dosage range, with plasma concentrations
being proportional to dose given. Alprazolam is almost
completely bioavailable following oral administration.
The bioavailability and pharmacokinetic characteristics
of Xanax Tablets or Xanax SR Tablets are comparable,
except for a slower rate of absorption of alprazolam
from Xanax SR Tablets. The slower absorption rate for
Xanax SR Tablets results in peak plasma alprazolam
concentrations that are approximately one-half that of
an equivalent dose of Xanax Tablets; peak concentrations
occur within one to two hours after a single dose of
Xanax Tablets, and 5 to 11 hours after a single dose of
Xanax SR Tablets.
Steady-state plasma concentrations are achieved within
three to four days of continuous dosing with either
dosage form. When equivalent daily doses are given,
steady-state peak and trough plasma alprazolam
concentrations for Xanax SR Tablets given once or twice
a day are comparable to Xanax Tablets given three or
four times a day.
Alprazolam and its metabolites are excreted primarily in
the urine. The predominant metabolites are
alpha-hydroxy-alprazolam, 4-hydroxy alprazolam, and a
benzophenone derived from alprazolam. Although they
possess some pharmacological activity, the plasma levels
of these metabolites are extremely low during chronic
dosing. In vitro, alprazolam is bound (80%) to human
serum protein.
The plasma elimination half-life of alprazolam has been
found to be about 11 to 15 hours in healthy adults. A
comparable elimination half-life for Xanax SR Tablets
indicates that the metabolism and elimination of
alprazolam are the same for both dosage forms.
Alprazolam clearance has been reported to be delayed in
patients with impaired hepatic and renal function,
alcoholism, in elderly or obese patients, and by the
co-administration of certain medicines.
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